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Updated: May 23, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
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Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

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解读MMP1+恶性子集对瘤免疫相互作用的影响:从单细胞和空间转录组学的见解

Da-Ming Xu1,2, Ling-Xiao Chen3, Ting Xue1,2

  • 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.

Cell death discovery
|May 20, 2025
PubMed
概括

矩阵金属蛋白酶1 (MMP1) 通过重塑瘤微环境来推动瘤生长和免疫逃避. 抑制MMP1可以增强抗瘤免疫力并改善患者的治疗结果.

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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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