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纤维肌痛患者和健康对照人群之间的大脑结构差异:基于来源的形态测量研究

Elijah Agoalikum^1,2, Hongzhou Wu^3,4, Benjamin Klugah-Brown⁵

¹Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China. agoalikumelijah@gmail.com.

Scientific reports

|May 20, 2025

概括

此摘要是机器生成的。

与健康个体相比,纤维肌痛患者表现出明显的脑结构差异. 特定大脑区域的灰质变化与纤维肌痛的疼痛感知和情绪困扰有关.

关键词:

慢性疼痛是一种慢性疼痛.组件组件组件组件组件这里是FM FM FM FM.这就是为什么MRI是MRI.catastrophizing 疼痛是一种灾难性的痛苦.这是SBM的SBM.

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科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
医学研究医学研究

背景情况:

纤维肌痛 (FM) 是一种慢性疼痛疾病,主要影响女性,与中枢神经系统 (CNS) 功能障碍有关.
了解FM中的结构性大脑变化对于开发有效治疗方法至关重要.

研究的目的:

通过基于来源的形态测量 (SBM) 来调查 FM 患者和健康对照人群 (HC) 之间的结构性大脑差异.
探索灰质体积变化与FM临床疼痛指标之间的关联.

主要方法:

使用SBM分析了20名FM患者和20名HC患者的结构磁共振成像 (sMRI) 数据.
采用多变量统计方法来确定灰色物质体积 (GMV) 的显著差异.

主要成果:

与HC相比,FM患者在双边丘脑中表现出更大的GMV.
在 FM 患者中,在双边门,皮,右小脑,右骨,右桃体和双边岛内观察到降低的 GMV.
白体的灰质缺陷与 catastrophizing,放大,反和无助的疼痛有明显的相关性.

结论:

结构性大脑变化,特别是在质体,面体,体和胰岛,都与FM的神经生物学有关.
这些发现表明脑结构,疼痛处理和FM中的情绪调节之间存在联系.
这些结果支持开发有针对性的疗法,以解决FM的神经生物学和心理方面的问题,以改善患者的治疗结果.