吸烟状态与衰老认知轨迹之间的关联解释了消耗偏差的偏差
Rachel Stuckwisch1, Aleena Bennett1, Anaïs Rouanet2
1Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
American journal of epidemiology
|May 20, 2025
概括
吸烟会对认知功能产生负面影响,特别是记忆力和语言流性. 这项研究使用了先进的统计方法来解释参与者的消耗,证实吸烟.
科学领域:
- 神经科学是一个神经科学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 关于吸烟对认知的影响,存在相互矛盾的发现.
- 生存偏差可能会影响以前的研究结果.
- 纵向研究中的磨损可能会导致结果偏差.
研究的目的:
- 研究吸烟状态对认知轨迹的影响.
- 在认知研究中解决潜在的消耗偏见.
- 提供关于吸烟和认知衰退的有力的证据.
主要方法:
- 从REGARDS队列研究中对21,216名参与者的分析.
- 使用线性混合模型 (LMM) 和联合模型 (JM) 进行灵敏度分析.
- 采用了根据MAR和eMAR假设的数据缺失的可靠统计方法.
主要成果:
- 当前吸烟者在基线和14年内表现出明显较低的复合认知评分,而不是从未吸烟者.
- 在记忆和口语流方面观察到负面影响.
- 来自LMM和JM分析的结果是一致的,支持这些发现.
结论:
- 吸烟与认知功能下降有关.
- 对于具有潜在消耗偏差的研究,建议使用联合模型.
- 这项研究加强了吸烟对认知的有害影响.
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