诺坎塔里丁促进M1巨细胞的两极分化,并抑制结直肠癌的生长
Xiao-Man Wei1,2, Si-Cheng Lu2,3, Liu Li1,2
1The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Acta pharmacologica Sinica
|May 20, 2025
概括
诺坎塔里丁 (NCTD) 通过重编程瘤微环境,有效地减少结直肠癌 (CRC) 的生长. 它促进M1巨细胞的两极分化,并抑制癌细胞的增殖和入侵.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 大肠直肠癌 (CRC) 呈现出免疫抑制和炎症微环境,导致治疗反应不佳.
- 来自Mylabris的诺坎塔里丁 (NCTD) 在癌症治疗中表现有前途.
- 了解NCTD对CRC的机制对于开发有效疗法至关重要.
研究的目的:
- 调查NCTD对结直肠癌 (CRC) 的抗瘤作用.
- 阐明NCTD在CRC中的作用的基本机制,重点关注瘤微环境和细胞通路.
主要方法:
- 在使用CT26和HCT116细胞系的小鼠中建立了皮下CRC模型.
- 在14天内将NCTD (2或4mg·kg−1·d−1) 输入腹膜内.
- 使用THP-1和RAW264.7细胞的体外试验 (流细胞计,qPCR) 来证实巨细胞极化,并评估CRC细胞的增殖,入侵和迁移.
主要成果:
- 在两种CRC模型中,NCTD剂量依赖性降低了瘤生长.
- NCTD显著增加了M1巨细胞的透和极化.
- NCTD增加了CSF2分泌,抑制了CRC细胞中的JAK2/STAT3信号,并抑制了CRC细胞的增殖,入侵和迁移.
结论:
- NCTD显示对结直肠癌有显著的抗瘤作用.
- NCTD通过CSF2-介导的M1巨细胞两极化重塑炎症微环境.
- 通过抑制癌细胞中的JAK2/STAT3通路,NCTD可以抑制CRC的进展.
关键词:
在CSF2中,CSF2是 CSF2 的一个组成部分.通过JAK2/STAT3路径.在M1巨细胞中.结肠直肠癌是什么意思诺坎塔里丁丁 (Norcantharidin) 是一种瘤微环境是一个微环境.更多相关视频
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