Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glial Cells01:04

Glial Cells

75.4K
Overview
75.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Bacterial infection reshapes monocyte and macrophage ontogeny at the CNS borders.

Science immunology·2026
Same author

Sustaining microglial reparative function enhances stroke recovery.

Nature·2026
Same author

Consensus statement on microglial and macrophage functions in gliomas.

Acta neuropathologica·2026
Same author

A transcriptomic microglia taxonomy across mouse and human pathologies.

Nature immunology·2026
Same author

CNS border macrophages in health and disease.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation.

Nature immunology·2026

相关实验视频

Updated: May 7, 2026

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury
13:28

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

Published on: September 4, 2013

11.5K

一个动态和多式模式的框架来定义微质状态.

Roman Sankowski1, Marco Prinz2,3

  • 1Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. roman.sankowski@uniklinik-freiburg.de.

Nature neuroscience
|May 20, 2025
PubMed
概括

微质细胞是中枢神经系统中的一个.

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 基因组学就是基因组学.

背景情况:

  • 单细胞RNA测序 (scRNA-seq) 已经导致识别了许多微质子集.
  • 目前的分类通常依赖于计算集群,可能过度简化微质异质性.
  • 微质是中枢神经系统 (CNS) 中必不可少的免疫细胞.

研究的目的:

  • 挑战离散微质子集的范式.
  • 为微质状态提出一个连续模型.
  • 解决微质研究中过度依赖计算集群的问题.

主要方法:

  • 重新评估scRNA-seq数据和计算集群方法.
  • 对微质细胞的转录多样性的分析.
  • 微质状态的连续模型的开发.

主要成果:

  • 微质中的转录多样性源于可塑性和技术噪音,而不是离散的子集.
  • 现有的术语经常描述重叠的细胞状态.
  • 一个受老化和分子背景影响的连续模型更好地代表了微质动态.

结论:

更多相关视频

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

10.5K
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

31.6K

相关实验视频

Last Updated: May 7, 2026

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury
13:28

Three-dimensional Confocal Analysis of Microglia/macrophage Markers of Polarization in Experimental Brain Injury

Published on: September 4, 2013

11.5K
In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

10.5K
Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
10:40

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

Published on: October 27, 2019

31.6K
  • 微细胞沿着连续存在,而不是作为离散实体.
  • 需要一种节的分类方法.
  • 一个连续模型为了解中枢神经系统中微质功能提供了一个强大的框架.