口服尿酸降低疗法的使用和有效性 经过格洛治疗:来自风湿病学网络数据库的发现
Lissa Padnick-Silver1, Andrew Concoff2, Hong-Ye Gao1
1Amgen, Inc., 1 Amgen Center Drive, Thousand Oaks, CA, 91320, USA.
口服尿酸降低疗法 (ULT) 对于不受控制的痛风在佩格洛治疗后是有效的. 接受较长佩格洛酶疗程的患者表现出更好的ULT成功,这表明潜在的尿酸负担减轻.
科学领域:
- 类风湿病学 类风湿病学
- 痛风管理 痛风管理
- 药物治疗 药物治疗
背景情况:
- 无法控制的痛风需要有效的尿酸降低策略.
- 佩格洛酶迅速降低血清尿酸盐 (SU) 水平.
- 佩格洛酶后的口服尿酸降低疗法 (ULT) 的疗效尚未得到充分证实.
研究的目的:
- 为了检查口服ULT在未经控制的痛风中接受格洛酶治疗后的使用和降低SU的疗效.
- 根据格洛酶治疗的持续时间来比较口服ULT疗效.
主要方法:
- 从2012-2022年对美国风湿病数据库 (UR-NICE) 的回顾性分析.
- 包括pegloticase治疗的患者和至少60天的随访数据.
- 定义的口服ULT疗效是SU<6mg/dL后启动;通过pegloticase疗程的长度和口服ULT启动的时间进行分析.
主要成果:
- 分析了211名患有未经控制的痛风的患者,54.5%的患者在 pegloticase 后开始口服ULT.
- 在66.1%的患者中,口服ULT在30天内开始.
- 佩格洛酶疗程较长的患者 (≥12次输注) 较有可能在口服ULT (78.4%对36.2%) 时达到SU<6 mg/dL.
结论:
- 大约三分之二的患有未经控制的痛风的患者在最后一次佩格洛酶输液后的30天内开始口服ULT.
- 较长的格洛酶治疗疗程与更高的口服ULT疗效相关,可能是由于更大的尿酸负担减轻.
- 口服ULT可能在成功的格洛酶治疗后有效;对尿酸负担影响的进一步研究是必要的.
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