视觉和定量F-FDG PET瘤-肝脏比率在放射性耐火差异化甲状腺癌:预后和潜在的预测值
Xian Li1,2, Hanhui Liu1,2, Shenghong Zhang1,2
1Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Molecular imaging and biology
|May 20, 2025
概括
-18氧葡萄糖正子发射断层扫描 (18F-FDG-PET) 的瘤与肝脏比 (TLR) 评分有效预测放射性耐药分化甲状腺癌 (RAIR-DTC) 患者的无进展生存率. 这种方法有助于对患者进行分层,以便更好地预测结果.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 抗放射性分化的甲状腺癌 (RAIR-DTC) 呈现出可变的进展,需要改进的预后工具.
- 目前用于预测RAIR-DTC进展的方法是不准确的,强调需要患者分层策略.
- 肝脏可以作为参考器官,用于在PET成像中标准化吸收测量.
研究的目的:
- 建立-18氧葡萄糖正子发射断层扫描 (18F-FDG-PET) 瘤与肝脏比率 (TLR) 评分,用于预测RAIR-DTC.结果.
- 在RAIR-DTC患者中评估视觉 (vTLR) 和定量 (qTLR) TLR分数的预后值.
- 评估不同TLR评分方法的可复制性和可靠性.
主要方法:
- 64名RAIR-DTC患者接受了基线18F-FDGPET/CT扫描.
- 根据肝脏吸收,患者被分为高TLR或低TLR组,使用视觉评估 (vTLR) 和定量测量 (qTLRmax,qTLRmean) 基于肝脏吸收.
- 无进展生存期 (PFS) 被分析为主要结局指标.
主要成果:
- 高TLR与低TLR组的分布在vTLR,qTLRmax和qTLR平均得分方法之间有所不同,观察到中度一致.
- 在所有评分方法中,与低TLR组相比,被归类为高TLR的患者始终显示PFS中位数明显较短 (vTLR:16.0 vs. 29.0个月,P=.010;qTLRmax:14.0 vs. 27.0个月,P=.041;qTLRmean:14.0 vs. 28.0个月,P=.004).
- 该vTLR得分显示出相当大的可重现性,并将其与qTLR得分相结合,提供了可靠的预后价值.
结论:
- 在RAIR-DTC中,TLR得分,特别是3D MIP PET图像上评估的vTLR,是PFS的有价值的预后指标.
- 定量TLR得分,当与视觉评估相结合时,提高RAIR-DTC结果预测的可靠性.
- 该TLR得分促进了患者分层,提供了一个精确的方法来预测RAIR-DTC的过程.
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