通过新的MNBI切线观察到GERD的更好的诊断准确性:越南的一项观察性研究
Hang Dao Viet1,2,3, Hue Luu Thi Minh4, Long Hoang Bao4,5
1Faculty of Internal Medicine, Hanoi Medical University, Hanoi, Vietnam. daoviethang@hmu.edu.vn.
BMC gastroenterology
|May 20, 2025
概括
平均夜间基线阻抗 (MNBI) 的新值有效地诊断越南患者的GERD. 1500欧姆的切线显示出高灵敏度和特异性,而2500欧姆可以排除疾病.
科学领域:
- 胃肠病学 胃肠病学
- 医学诊断 医学诊断 医学诊断
- 阻抗监测 阻抗监测 阻抗监测
背景情况:
- 平均夜间基线阻抗 (MNBI) 是多通道阻抗和pH (MI-pH) 监测的关键指标,用于诊断胃食道逆流病 (GERD).
- 现有的MNBI值在不同地理区域和测量系统中显示出差异性.
- 本研究使用越南患者的MI-pH数据研究了新的MNBI值,以提高GERD诊断.
研究的目的:
- 评估新的夜间平均基线阻抗 (MNBI) 值在怀疑患有GERD的越南患者的诊断效用.
- 在特定的地理人口中建立可靠的GERD诊断MNBI切线.
- 为了比较新的MNBI值与MI-pH监测中的现有指标的准确性.
主要方法:
- 对133名接受内镜检查,高分辨率计量 (HRM) 和24小时MI-pH监测的患者进行了回顾性分析.
- 患者根据异常,不确定的或正常的酸暴露时间 (AET) 分类为组.
- 使用接收器操作特征 (ROC) 曲线和曲线下面面积 (AUC) 分析评估的诊断准确性.
主要成果:
- 在异常AET的患者中观察到显著较低的MNBI.
- 在异常AET组中,MNBI<2292欧姆 (91.2%) 和<1500欧姆 (79.4%) 的患病率更高.
- 与其他MI-pH指标相比,MNBI在区分异常AET方面显示出最高的AUC (0.90).
- 一个新的1500欧姆的切线提供了比2292欧姆的值更好的特异性.
结论:
- 平均夜间基线阻抗 (MNBI) 截止值>1500欧姆表明在越南患者中诊断GERD的高灵敏度和特异性.
- 2500欧姆的MNBI切线可以有效地排除GERD在这个人群中.
- 新的MNBI值为研究的越南队列中GERD提供了更准确的诊断工具.
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