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病理特征与放射性耐火性复发性乳头甲状腺癌之间的关联:使用复发性样本进行突变分析

Thi Nhung Nguyen¹, Zhanna Mussazhanova^1,2, Hirokazu Kurohama¹

¹Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

BMC endocrine disorders

|May 20, 2025

概括

放射性耐火性 (RAI-R) 乳头甲状腺癌 (PTC) 与BRAF^V600E以及TERT促进体和BRAF的双重突变 (Dmut) 有关. 德穆特与RAI-R PTC的关联比单个突变更强.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
病理学病理学病理学

背景情况:

乳头甲状腺癌 (PTC) 通常是惰的,但转移性形式经常成为放射性耐火性 (RAI-R).
了解在复发性PTC中预测RAI-R的因素对于治疗策略至关重要.

研究的目的:

为了研究病理特征,BRAF^V600E和TERT促进子 (TERT-p) 突变在越南患者中具有RAI-R复发性PTC的作用.
为了确定在反复的PTC中RAI-R的预测因素.

主要方法:

这是一项对174例复发PTC病例 (135例RAI-R,39例RAI-avid) 的横截面研究.
使用后勤回归分析来评估病理特征,突变 (BRAF^V600E,TERT-p) 和RAI-R状态之间的关联.

主要成果:

极性/细胞凝聚力的丧失 (LOP/LCC) 仅在RAI-R复发性癌症中观察到.
BRAF^V600E突变和BRAF^V600E/TERT-p的双重突变 (Dmut) 是RAI-R的独立预测因素.
德穆特与RAI-R (OR=6.64) 的相关性明显强于单个突变 (斯穆特,OR=2.75).
BRAF^V600E和高细胞成分的组合是RAI-R.最强的预测因素.

结论:

RAI-R PTC独立地与BRAF^V600E和Dmut.相关联.
Dmut和RAI-R PTC之间的关联比Smut更强烈.
需要进一步研究线粒细胞计数和LOP/LCC在RAI-R PTC中的作用.

关键词:

在BRAF V600E中使用.TERT的发起人是 TERT 的发起人.线粒分裂 (mitosis) 是一种发生在细胞的过程.放射性耐火材料放射性耐火材料复发的乳头甲状腺癌高细胞的高细胞细胞.

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