Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

33.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
33.1K
Epigenetic Regulation01:46

Epigenetic Regulation

30.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
30.8K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.4K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.4K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

315
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
315
Gene-Environment Interactions01:20

Gene-Environment Interactions

233
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
233

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A GRADE-assessed systematic review and meta-analysis of randomized controlled trials evaluating the effects of olive leaf or olive pomace supplementation on cardiometabolic and anthropometric health markers.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

Smartphones and social media are harming youth health: A comprehensive public health response is overdue.

Health policy (Amsterdam, Netherlands)·2026
Same author

Food Structure Modulation of Antioxidant Bioaccessibility and Gut Epithelial Protection: The Case of Bread and Pasta Made With Pigmented Wheat.

Food science & nutrition·2026
Same author

New approach methodologies (NAMs) to support regulatory assessment of developmental immunotoxicity - a new PARC project.

Frontiers in toxicology·2026
Same author

Placental monoamine oxidase A activity in pregnancies complicated by maternal overweight/obesity and gestational diabetes mellitus.

Frontiers in endocrinology·2026
Same author

Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings.

Aging cell·2026

相关实验视频

Updated: May 23, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.7K

母亲的分娩经验和DNA甲基化.

Cyrielle Holuka1,2, Alessia Melacca3, Giorgia Menta4

  • 1Department of Infection and Immunity, Luxembourg Institute of Health, Esch-Sur-Alzette, Luxembourg.

Journal of developmental origins of health and disease
|May 20, 2025
PubMed
概括

母亲的分娩经历会影响婴儿的亲密关系和母乳养的持续时间. 然而,这项研究没有发现婴儿DNA甲基化与分娩压力相关的显著变化,这表明需要进一步研究.

关键词:
关于父母和孩子的艾文长度研究通过DNA甲基化.早期的生活 逆境 逆境全表观基因组协会研究研究.母亲生产经验的经验.心理健康 心理健康

更多相关视频

Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

13.3K
Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

25.5K

相关实验视频

Last Updated: May 23, 2025

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

18.7K
Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

13.3K
Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

25.5K

科学领域:

  • 生殖健康 生殖健康
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 围产期心理学 围产期心理学

背景情况:

  • 分娩显著影响母亲和新生儿的健康结果.
  • 产生的表观遗传影响 (EPIIC) 假设表明,劳动压力可以改变胎儿的基因表达.
  • 了解出生体验与婴儿表观遗传学之间的联系对于长期健康至关重要.

研究的目的:

  • 为了研究母亲的分娩经历和婴儿DNA甲基化之间的关系.
  • 探索母亲的分娩经历,母乳养时间和母亲和婴儿之间的联系.
  • 为了检查分娩对新生儿的表观遗传影响.

主要方法:

  • 利用了来自阿文长度研究的父母和孩子 (ALSPAC) 和ARIES子组 (1,022个母婴对) 的数据.
  • 评估母亲的分娩经验 (MBE),母亲和婴儿之间的联系,以及母乳养的持续时间.
  • 使用线性回归和全表观基因组关联研究 (EWAS) 进行统计分析.

主要成果:

  • 一半的母亲报告了负面的分娩事件;7%的母亲经历了三次或更多.
  • 负面的母亲分娩经历与更短的母乳养时间和较弱的母婴纽带相关.
  • 没有发现母亲的分娩经历和婴儿DNA甲基化 (CpG位) 之间的显著关联.

结论:

  • 积极的孕产妇分娩经历与更好的母婴纽带和母乳养有关.
  • 与母亲的分娩经历相比,没有检测到后代DNA甲基化的显著表观遗传变化.
  • 需要进一步的研究,以阐明母亲的分娩经历对儿童发育的长期健康影响.