肺囊 jiroveci 肺炎 感染 在 儿科 固体器官移植 接受者 肺炎 感染
Emily A Hayes1, Deipanjan Nandi1, Megan Lewis2
1The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.
Pediatric transplantation
|May 20, 2025
概括
肺囊性肺炎 (PJP) 在儿科移植患者中很少见,但存在风险,特别是在婴儿和心脏移植患者中. 这种感染导致严重的发病率,死亡率和医疗保健费用.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 移植免疫学 移植免疫学
- 免疫功能低下的主体感染性疾病.
背景情况:
- 肺炎 (PJP) 是免疫功能低下个体的一种严重感染.
- 儿科固体器官移植 (SOT) 接受者有患PJP的风险.
- 了解这一群体中PJP风险因素对于管理至关重要.
研究的目的:
- 在小儿SOT接受者中识别PJP的风险因素.
- 评估与PJP相关的发病率,死亡率和医疗保健资源利用率.
- 在当前的儿科SOT时代评估PJP发病率.
主要方法:
- 从2003年至2022年使用儿科健康信息系统数据库对儿科SOT接受者 (≤18岁) 的回顾性分析.
- 考克斯生存分析被用来确定PJP的风险因素.
- 分析了移植和随后的住院治疗的结果.
主要成果:
- 在18104名儿科SOT接受者中,PJP发生在0.3%的患者中,其中17%是突破性感染.
- 更高的PJP风险与心脏移植和心脏移植时的年龄<1年有关.
- PJP住院的平均住院时间为16天,平均费用为57,142美元,死亡率为9%.
结论:
- 儿科SOT患者中PJP是一种罕见但显著的移植后并发症.
- 婴儿和心脏移植接受者面临PJP的更高风险.
- 需要进一步的研究来完善这种脆弱人群的PJP预防策略.
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