一个系统的审查长期的SARS-CoV-2在免疫力低下的人身上流出
Rebecca C Christofferson1, Jennifer E Giovanni2, Emily H Koumans2
1Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.
Influenza and other respiratory viruses
|May 21, 2025
概括
免疫功能低下的患者可以在几个月内释放传染性SARS-CoV-2,即使没有症状. 连续测试对于确定这些人的隔离时间至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 长时间的SARS-CoV-2RNA检测在免疫受损的个体中被注意到.
- 在这个人群的呼吸器样本中对SARS-CoV-2持续时间的系统分析是有限的.
研究的目的:
- 系统地审查和描述SARS-CoV-2RNA和传染性病毒检测持续时间.
- 分析有关SARS-CoV-2感染的免疫功能低下患者的已公布数据.
主要方法:
- 对2020年1月1日至2022年7月1日期间发表的研究进行系统审查.
- 纳入标准:免疫功能低下的患者在呼吸道样本中发现SARS-CoV-2RNA>20天从症状发作或首次阳性RT-PCR.
主要成果:
- 平均SARS-CoV-2RNA检测时间为56天 (上呼吸道) 和60天 (下呼吸道).
- 能够复制的SARS-CoV-2被检测到从症状发作开始的中位数为60.5天.
- 持续时间根据肺炎和潜在的免疫抑制条件 (血液恶性瘤与固体器官移植) 显著变化.
结论:
- 免疫功能受损的个体可以长时间内藏复制能力强的SARS-CoV-2,包括无症状的.
- 连续的SARS-CoV-2测试对于指导免疫功能低下患者隔离时间至关重要.
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