Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

7.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
7.8K
Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

730
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
730
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

597
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
597
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

790
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
790
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

952
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
952
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

753
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
753

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Ca <sup>2+</sup> -Sensitivity of Contraction is Increased in the Left Atrium and Left Ventricle of Patients with Ischemic Heart Failure.

bioRxiv : the preprint server for biology·2026
Same author

Computational Modelling of Selective Capture Mechanisms in Conduction System Pacing.

Annals of biomedical engineering·2026
Same author

Tau20-RETROmapping System Identifies Driver-Like Activation Patterns in Real-Time During Persistent Atrial Fibrillation.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Comparative multimodal calibration of patient-specific atrial fibrillation models: Impact of imaging and electrophysiology data on arrhythmogenic substrate identification.

The Journal of physiology·2026
Same author

Role of interatrial connection ablation in re-entry dynamics: an in silico evaluation.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Assessing the importance of sex and disease-specific anatomy in electrophysiology and mechanical simulations with a newly developed public virtual cohort of four-chamber heart models.

PLoS computational biology·2026

相关实验视频

Updated: May 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K

对于左束枝优化心脏重同步治疗的心室-心室延迟编程的in silico指南.

Marina Strocchi1, Jack W Samways1, Akriti Naraen1

  • 1National Heart and Lung Institute, Imperial College London, 72 Du Cane Road, London W12 0NN, UK.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
|May 21, 2025
PubMed
概括

优化心室-心室延迟 (VVD) 对于左束枝节奏 (LBBP) 优化的心脏重同步治疗 (LOT-CRT) 是至关重要的. 理想的VVD设置取决于左心室 (LV) 延迟的具体原因和步调捕获方法,以改善LV激活.

关键词:
心脏再同步治疗心脏再同步治疗计算模型 计算模型导电基板是一种导电基板.导电系统的节奏调节静脉-心室延迟 静脉-心室延迟

更多相关视频

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

14.4K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

349

相关实验视频

Last Updated: May 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.4K
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

14.4K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

349

科学领域:

  • 心脏病学 心脏病学
  • 生物医学工程 生物医学工程
  • 计算建模 计算建模

背景情况:

  • 心脏再同步治疗 (CRT) 优化了左心室 (LV) 的激活.
  • 在标准CRT无效时,以左束分支节奏 (LBBP) 优化的CRT (LOT-CRT) 提供了替代方案.
  • 对于LOT-CRT,心室-心室延迟 (VVD) 的最佳编程仍未确定.

研究的目的:

  • 为了确定LOT-CRT的最佳VVD编程.
  • 调查不同LV导电基板对VVD优化的影响.
  • 评估节奏捕捉类型对VVD设置的影响.

主要方法:

  • 在24个解剖学中对心室激活的计算建模.
  • 模拟扩散的LV导电系统延迟和心肌内延迟.
  • 模拟LOT-CRT具有选择性或心肌捕获 (LV隔膜节奏) 和可变的VVD.
  • 对模型与临床数据的验证.

主要成果:

  • 扩散的LV导电延迟的最佳VVD是负的 (LBBP节奏首先).
  • 最佳VVD为LV心肌内脏疾病有利于鼓动冠状动脉鼻LV首先.
  • 在LOT-CRT中心肌捕获有利于负VVD设置.

结论:

  • 对LOT-CRT的最佳VVD取决于LV激活延迟的潜在机制.
  • 在LOT-CRT中实现的电捕获类型显著影响最佳VVD.
  • 个性化VVD优化对于有效的LOT-CRT治疗至关重要.