心力衰竭中吸收性转细胞体的增加和紧接口的弱点同样可以通过运动训练和洛萨坦治疗来纠正
Hiviny de Ataides Raquel1, Mariana Makuch-Martins1, Sany M Perego1
1Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, São Paulo, Av. Prof. Lineu Prestes, 1524, SP 05508-000Brazil.
Clinical science (London, England : 1979)
|May 21, 2025
概括
心力衰竭导致血脑屏障 (BBB) 泄漏,导致自主失衡. 运动和洛萨坦治疗通过降低大脑血管激素II,恢复BBB功能并改善心脏自主控制.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 心力衰竭 (HF) 的特征是心室功能减弱,氨酸酶系统 (RAS) 激活和交感兴奋.
- 自主核中的血脑屏障 (BBB) 功能障碍有助于HF的自主失衡.
- 运动训练 (T) 已被证明可以使BBB功能正常化并改善自主控制.
研究的目的:
- 为了确定由HF诱导的BBB病变背后的机制.
- 阐明运动诱导的BBB修复和自主控制正常化的机制.
- 调查局部血管新素II (Ang II) 和微质激活在下丘脑副心脏核 (PVN) 内BBB调节中的作用.
主要方法:
- 由于冠状动脉结合引起的HF,Wistar大鼠接受了洛萨坦 (Los) 或车载 (Veh) 治疗,并接受了运动训练 (T) 或久坐 (S) 协议.
- 进行了血液动力学和自主记录,BBB透性评估和脑毛细血管 (TJ,囊泡贩运) 的超结构分析.
- 在PVN中评估了局部Ang II表达,微质激活 (IBA-1) 和Ang II-微质相互作用.
主要成果:
- 高频率大鼠 (Veh-S) 表现出高的同情活动,BBB透性,囊泡运输和紧结 (TJ) 弱点.
- 运动训练 (Veh-T),洛萨坦 (Los) 和组合疗法 (Los-T) 都纠正了这些由HF引起的异常.
- 在HF中增加的PVN Ang II和微质激活被T,Los和它们的组合减少,而Ang II调节微质表型和BBB运输.
结论:
- 在高频的背景下,PVN Ang II可用性的变化是跨细胞和半细胞运输在BBB的关键调节者.
- 运动训练和洛萨坦治疗通过调节Ang II信号和微质激活来改善HF诱导的BBB功能障碍.
- 向大脑宁-血管酶系统提供了一种潜在的治疗策略,用于改善心力衰竭的自主控制.
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