开发和应用模块化MasSpec笔系统用于临床阿片类药物查
Abigail N Gatmaitan1, Kathryn Weaver2, Sunil P Badal1
1Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Analytical chemistry
|May 21, 2025
概括
一个新的模块化MasSpec Pen (MSPen) 系统允许从皮肤表面直接,非破坏性的阿片类药物查. 这项技术通过分离采样和质谱 (MS) 分析来简化工作流程,以快速检测阿片类药物.
科学领域:
- 分析化学 分析化学
- 法医科学 法医科学 法医科学
- 生物医学工程 生物医学工程
背景情况:
- 质谱 (MS) 为小分子分析提供了高灵敏度和特异性,这对于阿片类药物查至关重要.
- 寻求直接检测方法来简化患者查工作流程.
- 目前的方法可能需要复杂的样本准备或缺乏直接性.
研究的目的:
- 开发和应用一个模块化MasSpec Pen (MSPen) 系统用于阿片类药物查.
- 为灵活和快速的阿片类药物检测脱取样本和MS分析.
- 评估MSPen系统的性能,用于从人类皮肤直接分析阿片类药物.
主要方法:
- 开发一个模块化MSPen系统,将采样和MS分析分开.
- 使用电喷气电离化MS用于检测各种阿片类药物 (氧化,,芬太尼,,吗啡).
- 分析了阿片类药物标准和注射过的人体皮肤,随后对患者皮肤,尿液和唾液进行了临床测试.
主要成果:
- 在表面和皮肤上的阿片类药物单个纳米克范围内达到检测和量化极限.
- 从患者皮肤直接取阿片类药物样本的模块化MSPen系统的可行性证明.
- 展示了直接从皮肤表面获得的阿片类药物的半量化,与尿液和唾液测试相似.
结论:
- 模块化MSPen系统可以从表面和皮肤上直接,非破坏性地采样和半量化阿片类药物.
- 这项技术为阿片类药物查提供了简化和加快的方法.
- 在药物查和诊断方面,MSPen系统具有更广泛的应用潜力.
相关概念视频
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
200
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
200
01:19MALDI-TOF Mass Spectrometry
4.6K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.6K
01:25Analgesia and Pain Management
415
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
415