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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

730
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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在类风湿性疾病中与粘膜相关的不变T细胞.

Manon Lesturgie-Talarek1, Virginie Gonzalez1, Lucie Beaudoin1

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概括

粘膜关联不变T细胞 (MAIT) 对于免疫至关重要,在风湿性疾病中减少,但在炎症组织中积累. 这些发现突出了MAIT细胞.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 类风湿病学 类风湿病学
  • 细胞生物学 细胞生物学

背景情况:

  • 粘膜关联不变T细胞 (MAIT) 是天生的类似T细胞,通过MR1识别微生物代谢物.
  • MAIT细胞在激活后迅速产生促炎和细胞毒性介质.
  • 它们与微生物群的相互作用和组织积累使它们涉及炎症状况.

研究的目的:

  • 审查最近在主要类风湿性疾病中对MAIT细胞的发现.
  • 探索MAIT细胞在炎症性类风湿病的发病过程中的作用.

主要方法:

  • 关于MAIT细胞在类风湿性关节炎,脊柱性关节炎,牛皮性关节炎,全身性红斑狼,全身性硬化症,原发性Sjögren综合征和皮肤肌炎中的研究的文献综述.
  • 在这些疾病中分析MAIT细胞频率,表型和组织分布.
  • 检查来自小鼠模型的证据.

主要成果:

  • 在大多数研究的类风湿性疾病中,循环MAIT细胞频率下降.
  • 剩余的MAIT细胞往往表现出活性化表型,增强了细胞因子的产生.
  • 在诸如类风湿性关节炎和Sjögren综合征等疾病中,MAIT细胞在炎症组织中得到丰富.
  • 在相关的小鼠模型中,MAIT细胞有助于疾病的进展.

结论:

  • MAIT细胞参与炎症性风湿性疾病的免疫病原发生.
  • MAIT细胞可能会迁移到炎症组织,导致局部炎症.
  • MAIT细胞代表了类风湿性疾病的潜在治疗点.