新兴和重新出现的病原体导致血流感染 (BSI) 在第三级护理医院住院患者
Shubhransu Patro1, Smrutisree Mohapatra2, Arushi Choudhary1
1General Medicine, Kalinga Institute of Medical Sciences, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Bhubaneswar, IND.
Cureus
|May 21, 2025
概括
新兴和重新出现的 (E&Re) 病原体会导致血液感染 (BSI). 这项研究确定了像Burkholderia cepacia这样的E&Re病原体,它们对抗生素的敏感性,并强调使用配对血培养来准确诊断.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 细菌学 细菌学是一门学科.
背景情况:
- 血流感染 (BSI) 是由血液中的微生物引起的危及生命的疾病.
- 新兴和重新出现的 (E&Re) 病原体对住院患者构成重大威胁,经常挑战传统的识别方法.
- 自动化系统为BSI提供了改进的识别和抗生素敏感性测试.
研究的目的:
- 确定导致BSI的新发现的E&Re细菌和真菌病原体的频率.
- 分析这些E&Re病原体的抗生素敏感性模式.
- 调查与E&Re病原体相关的风险因素和BSI后结果.
主要方法:
- 在布巴内斯瓦尔的KIMS进行了两年 (2022年6月至2024年5月) 的回顾性研究.
- 血液样本使用自动化血液培养系统 (BacT/Alert 3D) 进行处理,并使用VITEK 2识别/测试敏感性.
- 从电子记录中收集并分析的数据.
主要成果:
- 在31,850个血液培养物中,5730个 (18%) 呈阳性,其中2,718个 (47.43%) 来自配对的瓶子.
- 总共有430个 (15.82%) 的E&Re病原体被分离出来,包括363种细菌和67种 (15.58%) 的Candida auris.
- 主要的细菌病原体是Burkholderia cepacia (29.30%),Sphingomonas paucimobilis (15.34%),以及Elizabethkingia meningoseptica (12.55%).这些病原体中主要存在的是Burkholderia cepacia (29.30%),Sphingomonas paucimobilis (15.34%) 和Elizabethkingia meningoseptica (12.55%),这些病原体中主要存在的是Burkholderia cepacia (29.30%),Sphingomonas paucimobilis (15.34%) 和Elizabethkingia meningoseptica (12.55%). 伯克霍尔迪亚 (Burkholderia cepacia) 显示对和米诺环素的敏感性.
结论:
- 配对血培养,临床病史和抗生素病史对于准确的BSI病原体识别和治疗至关重要.
- 血液培养中的E&Re病原体不应被视为污染物,需要立即注意.
- 自动化系统有助于及时报告,并允许早期,精确管理由E&Re病原体引起的BSI.
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