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Updated: May 23, 2025

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Activating Autophagy by Aerobic Exercise in Mice
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运动可以调节人类的自吗? 一个系统的审查和元分析
Xiang-Ke Chen1, Chen Zheng2, Parco Ming-Fai Siu3
1Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.
Autophagy reports
|May 21, 2025
概括
运动会根据类型和组织对人体自产生不同的影响. 抵抗运动会急性抑制自但慢性增强它,而耐力运动没有显著的影响. 骨肌和PBMCs表现出相反的反应.
科学领域:
- 细胞生物学 细胞生物学
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 宏自/自是一种关键的细胞循环过程,与各种生物功能和疾病有关.
- 虽然动物研究表明运动可以调节自并提供健康益处,但人类的证据仍然不确.
研究的目的:
- 系统地审查和对人体研究对运动对蛋白质水平上的自的影响进行元分析.
- 为了澄清不同运动方式与人类的自调节之间的关系.
主要方法:
- 在MEDLINE,Embase,Cochrane,Scopus和Web of Science数据库中进行系统搜索,截至2022年9月.
- 包括研究运动对自蛋白的影响的人类研究,遵守PRISMA指南.
- 使用随机效应模型进行的元分析.
主要成果:
- 26项研究表明,急性抵抗运动减弱了自 (LC3-II下降,SQSTM1增加),而长期抵抗运动增强了自 (LC3-II增加,SQSTM1减少).
- 中等到强烈的耐力运动,急性或长期,没有显著改变LC3-II水平.
- 运动诱导了骨肌肉 (抑制) 和外周血液单核细胞 (激活) 之间的自的对立作用.
结论:
- 身体炼以一种取决于炼方式和组织类型的方式调节人类的自.
- 需要进一步的研究来充分阐明这些复杂的相互作用.
- 建议为调节人类的自而量身定制的运动处方.
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