由高禁食血葡萄糖引起的缺血性中风负担的持续挑战:全球视角
Zhenhai Sun1, Menghe Zhang2, Yaoyao Zuo2
1Second School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in endocrinology
|May 21, 2025
概括
高速血葡萄糖 (HFPG) 显著增加了全球缺血性中风负担,死亡和DALY自1990年以来翻了一番. 尽管利率下降,但未来的趋势预计将有所下降,强调针对风险人群的有针对性的战略.
科学领域:
- 全球卫生流行病学
- 心血管疾病研究研究
- 代谢综合征研究 代谢综合征研究
背景情况:
- 缺血性中风是全球死亡和残疾的主要原因.
- 高速血葡萄糖 (HFPG) 是缺血性中风的关键,可修改的风险因素.
- 了解可归因于HFPG的疾病负担对于公共卫生干预至关重要.
研究的目的:
- 评估归因于HFPG的缺血性中风的全球疾病负担.
- 分析过去30年来与HFPG相关的缺血性中风负担的趋势.
- 预测未来15年这种疾病负担的未来趋势.
主要方法:
- 利用了2021年全球疾病负担 (GBD) 的比较风险评估方法.
- 使用死亡率,残疾调整寿命年 (DALYs) 和年龄标准化率量化疾病负担.
- 采用贝叶斯年龄周期队列 (BAPC) 建模用于趋势分析和预测,以及不平等和分解分析.
主要成果:
- 在2021年,HFPG引起的缺血性中风导致全球659,378人死亡,12371,434人DALY,自1990年以来翻了一番.
- 根据年龄标准化的死亡率和DALY率在30年内显著下降 (EAPC分别为-0.96和-0.72).
- 负担正在向社会人口指数 (SDI) 较低的地区转移,不成比例地影响男性和老年人群;人口增长和老龄化是关键驱动因素.
结论:
- 尽管年龄标准化率下降,但HFPG导致的缺血性中风的绝对负担在全球范围内正在增加.
- 这突显了一个持续的公共卫生挑战,需要持续关注.
- 未来的战略必须针对SDI较低的地区的人口,特别是中年和老年男性.
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