剖析胃肠道和内分泌疾病进展之间的双向关联
Hongyan Liu1,2, Shucheng Si1,2, Hua Zhang1,2
1Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Frontiers in endocrinology
|May 21, 2025
概括
胃肠道和内分泌系统疾病是内在联系在一起的,每一种情况都会增加患另一种疾病的风险. 这种双向关联在整体,个体和并发性疾病中观察到,突出显示了疾病进展的显著联系.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 胃肠道 (GI) 和内分泌疾病之间的内在联系尚未得到充分理解.
- 现有的研究还没有完全阐明这些关联的双向性质.
- 了解这种关系对于全面的疾病管理至关重要.
研究的目的:
- 调查胃肠道和内分泌疾病之间的双向关联.
- 分析整体,个体和并发性胃肠道疾病对内分泌疾病发展的影响.
- 检查整体,个体和并发性内分泌疾病对胃肠道疾病发展的影响.
主要方法:
- 使用双向前性队列研究设计.
- 包括来自英国生物库的45万多名参与者,在基线没有胃肠道或内分泌疾病.
- 采用多变量Cox比例危险模型来估计危险比率 (HRs) 和95%置信区间 (CI).
主要成果:
- 整体肠道疾病增加了发生内分泌疾病的风险 (HR,1.22;95% CI,1.19-1.25).
- 总体内分泌疾病增加了发生性胃肠道疾病的风险 (HR,1.48;95% CI,1.44-1.53).
- 在2型糖尿病和各种胃肠道疾病之间,以及甲状腺疾病/甲状腺过硬和胃肠道疾病之间,发现了特定的双向关联. 增加的并发症数与整体肠道和内分泌疾病的风险更高相关.
结论:
- 证实了胃肠道和内分泌疾病之间广泛的双向关联.
- 这种联系存在于整体疾病类别,个体疾病和不同数量的并发症中.
- 这些发现强调了这两个器官系统在疾病发病过程中的相互联系.
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