这就是WAR:AMR的价格
Laura J Rojas1,2,3, Tracy L Lemonovich4,5, Steven H Marshall3
1Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
JAC-antimicrobial resistance
|May 21, 2025
概括
一名受战争伤的乌克兰士兵患上了耐卡巴尼姆的Klebsiella肺炎感染. 有效的治疗包括ceftazidime/avibactam和aztreonam,为冲突地区的类似多药耐药感染提供了希望.
科学领域:
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 乌克兰冲突增加了战争受伤患者多药耐药 (MDR) 细菌感染的风险.
- 冲突造成的创伤伤害为严重的细菌殖民和感染创造了机会.
研究的目的:
- 报告战争中受伤的士兵成功治疗了耐卡巴尼姆的Klebsiella肺炎感染.
- 使用全基因组测序 (WGS) 鉴定感染菌株的特征,并确定耐药性机制.
- 评估特定抗生素治疗方案的疗效.
主要方法:
- 一名乌克兰士兵的案例报告,患有创伤性下肢损伤和随后的MDR感染.
- 从手术伤口培养物中分离和识别抗卡巴因的Klebsiella肺炎菌.
- 全基因组测序 (WGS) 的Klebsiella pneumoniae分离,以确定其菌株,毒性因子和耐药基因 (包括blaNDM-1).
- 临床管理和治疗反应评估.
主要成果:
- 成功治疗因耐卡巴尼姆的Klebsiella肺炎感染而复杂的创伤性损伤.
- 据WGS鉴定,该分离物是一种高毒性ST147菌株,具有多种耐药性和毒性因素,包括blaNDM-1基因.
- 患者对使用塞夫塔齐迪姆/阿维巴克坦和阿兹特里奥纳姆的治疗有了有效的反应.
结论:
- 塞法胺/阿维巴克坦和阿兹特雷诺姆在武装冲突的背景下,代表了管理多抗药性感染的有希望的治疗选择.
- 基因组监测对于了解和打击战区抗药性病原体的传播至关重要.
- 这个案例突出了在冲突期间受伤的患者治疗严重感染的挑战和成功策略.
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