怀孕期间母亲的抑郁症和儿童的身体发育
Di Pi1,2, Shuifang Lei1,2, Wenjing Chang3
1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Journal of biomedical research
|May 21, 2025
概括
产前抑郁症显著增加了儿童超重和肥胖的风险. 怀孕期间母亲的抑郁症状与36个月以下儿童的不良生长轨迹有关.
科学领域:
- 围产期心理健康问题
- 童年发展儿童的发展.
- 公共卫生 公共卫生
背景情况:
- 产前母亲的心理痛苦,特别是抑郁症,被认为是影响胎儿生长的因素.
- 产前抑郁症对早期儿童发育的影响,包括生长轨迹和肥胖风险,需要进一步调查.
研究的目的:
- 调查产前抑郁症与1至36个月的儿童生长轨迹之间的联系.
- 检查与产前抑郁症相关的儿童超重和肥胖的几率,考虑到母亲的焦虑和压力.
主要方法:
- 分析了江苏出生队列中4710个母婴双的数据.
- 在三个月内评估母亲的心理痛苦,分为轻度,中度和重度抑郁症组.
- 利用体重对长度z-score (WLZ) 和轨迹模型来评估超重/肥胖和生长模式;用于分析的概括估计方程 (GEE).
主要成果:
- 增加产前抑郁症状与28%至41%更高的儿童超重/肥胖的几率在所有三个月.
- 确定了五种不同的WLZ增长轨迹模式.
- 患有更严重抑郁症状的母亲的孩子有39%-47%的更高的可能性遵循一个非常高的稳定增长轨迹.
结论:
- 产前抑郁症显著影响不良的生长模式,并增加了儿童超重和肥胖的风险.
- 这些发现强调了针对怀孕期间母亲心理健康的早期干预策略的迫切需要.
- 怀孕期间母亲的心理压力对孩子的发育和健康状况有持久的影响.
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