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淋巴细胞食道炎和酸性食道炎之间的比较分析:一个回顾性横截面研究

Mukundkumar V Patel¹, Maitri M Patel², Dhara K Patel³

¹Department of Medicine, Annaya College of Medicine and Research, Kalol, Gujarat, India.

Recent advances in inflammation & allergy drug discovery

|May 21, 2025

概括

淋巴细胞性食道炎 (LyE) 是一种罕见的疾病,经常被误认为是eosinophilic食道炎 (EoE). LyE主要影响具有自身免疫性疾病的老年女性,而EoE影响具有亚托皮性疾病的年轻男性.

科学领域:

胃肠病学胃肠病学
病理学病理学病理学
内部医学内部医学

背景情况:

淋巴细胞性食道炎 (LyE) 和酸性食道炎 (EoE) 具有相似的临床和内镜特征,但在预后和治疗方面有所不同.
LyE是一种未被认可的食道炎形式,需要对其独特特征进行进一步调查.

研究的目的:

为了比较LyE和EoE患者之间的临床症状,危险因素和内镜检测结果.
通过比较分析来区分LyE与EoE和其他食道疾病.

主要方法:

医疗记录的回顾性审查,食管胃管腺镜检查 (EGD) 发现,以及18岁以上患者的活检数据.
在LyE,EoE,非特异性食道炎 (NSE) 和正常食道组织学 (NEH) 组之间比较人口统计数据,临床特征,危险因素和EGD发现.

主要成果:

LyE (1.25%的病例) 在老年女性 (平均年龄54.81岁) 中更为普遍,与自身免疫性疾病和食不良和消化不良等症状相关.
在年轻男性 (平均年龄为43.52岁) 中,EoE (8.96%的病例) 更常见,与亚托皮性疾病有关,并以食物影响为特征.
内镜发现重叠,但LyE显示出更多的食道炎和狭窄,而EoE有更多的环和.

结论:

准确的组织病理学诊断对于区分LyE与EoE至关重要,因为人口结构,风险因素和临床表现不同.
LyE的特点是年龄较大,女性性别和自身免疫性并发症,与EoE与年龄较小,男性性别和亚托皮有关.
这项研究强调了认识到LyE作为食道炎症疾病中的一个独特实体的重要性.

关键词:

消化道胃肠腺镜检查埃索诺菲尔性食道炎 (eosinophilic esophagitis) 是一种导致食道炎的疾病.食道活检是食道活检.淋巴细胞性食道炎淋巴细胞性食道炎非特异性食道炎. 非特异性食道炎.

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