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利斯佩里作为双相情感障碍患者强迫症症状的辅助治疗:一种随机,双盲,安慰剂控制的临床试验
Ali Sahraian1, Mahsa Ghavipisheh1, Leila Razeghian Jahromi1
1Research Center for Psychiatry and Behavioral Sciences, School of Medicine, Shiraz University of Medical Sciences.
International clinical psychopharmacology
|May 21, 2025
概括
里斯佩里有效地减少了双相情感障碍 (BD) 患者的强迫症 (OCD) 症状. 这种治疗是安全的,耐受性很好,比安慰剂显著改善症状.
科学领域:
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 在双相情感障碍 (BD) 患者中治疗强迫症 (OCD) 症状具有重大临床挑战.
- 同时出现的BD和OCD症状需要谨慎的治疗管理.
研究的目的:
- 为了研究RISPERIDONE在减少患有OCD的患者中强迫症症状的疗效和安全性.
- 为了评估risperidone在患有强迫症症状的euthymic BD患者的治疗效果.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的试验.
- 42名患有同时出现BD和OCD症状的患者被随机分配给接受Risperidone或安慰剂.
- 强迫症症状在基线和4,8,12周使用耶鲁-布朗强迫症强迫行为量表 (YBOCS) 进行评估.
主要成果:
- 在12周后,与安慰剂组相比,RISPERIDONE组的YBOCS得分明显较低 (5(3) 和11(6.5),P<0.001).
- 里斯佩里组中显著更高比例的患者在YBOCS得分中实现了>35%的降低 (95.23%与47.61%相比,P = 0.001).
- 在基线时,在两组之间没有观察到YBOCS得分的显著差异.
结论:
- 里斯佩里在减轻双相情感障碍患者的强迫症症状方面表现出显著的有效性.
- 这项研究表明,瑞斯佩里是这种患者群体的安全和耐受性良好的治疗选择.
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