认知障碍与外围动脉疾病 (PAD) 的关联:系统性审查
Beth L Cheshire1, Sarah J Messeder1,2,3, Coral J Pepper4
1Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Vascular medicine (London, England)
|May 21, 2025
概括
周围动脉疾病 (PAD) 与认知能力下降有关,包括记忆和处理速度问题. 在PAD患者中早期查认知障碍可能会改善诊断和管理.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 老年病的医生 老年病的医生
背景情况:
- 周围动脉疾病 (PAD) 影响血管健康,并可能影响大脑功能.
- 认知障碍和痴呆症是重大的公共卫生问题,特别是在老年人群中.
研究的目的:
- 系统地审查和综合关于外围动脉疾病 (PAD) 与认知障碍或痴呆症之间的联系的证据.
- 通过使用暴露效应非随机研究中偏差风险 (ROBINS-E) 工具来评估包含的研究的质量.
主要方法:
- 在MEDLINE,Embase,CINAHL,PsycINFO和CENTRAL数据库中进行系统的文献搜索.
- 包括38项研究 (58,586名参与者) 报告了PAD (脚-手臂指数≤0.9) 和成年人的认知功能.
- 由认知结果和研究设计构建的发现的叙述综合.
主要成果:
- 周围动脉疾病 (PAD) 与认知障碍有关,特别是影响记忆和处理速度.
- 横截面和纵向研究都表明,PAD患者的认知表现较差,认知障碍风险增加.
- PAD与痴呆症风险增加有关,与纵向研究中的危险比率相比,横截面研究中的几率比率更高.
结论:
- 有证据表明,PAD与认知障碍独立相关,无论其他心血管风险因素如何.
- 临床医生应该意识到PAD患者的认知障碍患病率,因为它会影响治疗坚持和生活方式参与.
- 在PAD人群中查认知障碍可能有助于早期诊断和管理,尽管需要进一步研究PAD治疗的认知益处.
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