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在接受急性淋巴细胞白血病化疗的中国儿童中身高和体重指数的变化
Yixiao Chen1,2, Jing Miao1,2, Xinyi Liang2,3
1Division of Hematology/Oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China.
Nutrition and cancer
|May 21, 2025
概括
用化疗治疗的儿科急性淋巴细胞白血病 (ALL) 患者经历了身高缺陷和BMI增加,特别是在前三个月. 追赶增长发生在以后,因年龄和风险因素而有所变化.
科学领域:
- 儿科瘤学 儿科瘤学
- 内分泌学 在内分泌学.
- 临床研究 临床研究
背景情况:
- 患有急性淋巴细胞白血病 (ALL) 的儿童面临身高缺陷和肥胖的风险.
- 关于仅接受化疗的中国儿科ALL患者的数据有限.
研究的目的:
- 分析化学治疗中中国儿科ALL患者的人体变化.
- 为了确定影响身高和BMIz-score在治疗期间和治疗后变化的因素.
主要方法:
- 在805名儿科ALL患者的身高和BMIz分数的纵向分析.
- 从诊断到治疗开始两年后收集的数据.
- 统计分析用于评估变化和影响因素.
主要成果:
- 在治疗期间观察到显著的身高z-score降低和BMIz-score增加 (p < 0.001).
- 最明显的变化发生在最初的三个月,在9个月后发现了追赶增长.
- 年龄 (8-13岁) 和高风险状况与较大的身高缺陷相关;较小的儿童 (<9岁) 和非高风险组显示BMI增加较大.
结论:
- 儿科ALL的化疗诱导身高缺陷和BMI增加.
- 年龄和风险分层影响了这些人体变化的严重程度.
- 在化疗期间和之后,监测生长和BMI对于儿科ALL患者至关重要.
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