结核病与病风险之间的关联:系统性审查和元分析
Sawai S Rathore1, Shifa P Shaikh2, Hyder R Zaidi3
1Dr. Sampurnanand Medical College, Jodhpur, India.
Minerva gastroenterology
|May 21, 2025
概括
结核病 (CD) 显著增加了病的风险,包括淋巴结核炎和末期病 (ESRD). 在CD患者中,早期监测功能对于预防并发症至关重要.
科学领域:
- 胃肠道学和脏学
- 自身免疫性疾病 自身免疫性疾病
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 病 (CD) 是一种自身免疫性疾病,疑似与慢性病 (CKD) 有联系,但报告不一致.
- 之前关于CD和病风险之间的关联的研究已经产生了相互矛盾的结果.
- 这一元分析旨在澄清CD与病发病率之间的关系.
研究的目的:
- 研究乳病与患各种病的风险之间的关联.
- 量化病患者病的综合患病率.
- 评估患有CD的个体患有特定病的风险,包括球炎和末期病 (ESRD).
主要方法:
- 在PubMed,Embase和Google Scholar进行了系统的文献搜索,截至2024年3月31日.
- 在分析中包括了9项涉及2,022,686名患者的观察性研究.
- 随机效应模型被用于计算CD和病风险之间的关联的聚合几率比率 (ORs) 和95%置信区间 (CI). 研究质量使用纽卡斯尔-太华尺度 (NCOS) 进行评估.
主要成果:
- 在CD患者中,整体病,血球炎和ESRD的综合患病率分别为2.29%,1.31%和1.55%.
- 结核病与整体病 (OR=1.98),结核炎 (OR=2.68) 和ESRD (OR=2.58) 的风险增加显著相关.
- 纳入的研究通常质量高或中等,没有发现显著的出版偏差.
结论:
- 患有乳病的患者患上病的风险较高,包括淋巴结膜炎和ESRD.
- 定期监测功能和有效治疗腹腔疾病对于减轻损伤至关重要.
- 需要进一步的研究来阐明潜在的机制,并制定针对性干预措施,以治疗CD患者的脏并发症.
相关概念视频
Renal Corpuscle
1.4K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.4K
Nephrons
1.9K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.9K
Kidney Structure
68.3K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.3K
Psychoneuroimmunology: Diabetes and Cancer
20
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
20
External Anatomy of the Kidney
641
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
641
Autoimmune Disorders
366
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
366


