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对自闭症谱系障碍的非典型抗精神病药物:一个网络元分析
Nicolás Meza1, Juan Va Franco2, Yanina Sguassero3
1Interdisciplinary Centre for Health Studies CIESAL, Universidad de Valparaíso, Viña del Mar, Chile.
The Cochrane database of systematic reviews
|May 21, 2025
概括
里斯佩里和阿里皮普拉可能会降低患有自闭症谱系障碍 (ASD) 的儿童的烦躁情绪. 关于其他症状和副作用的证据是不确定的,这凸显了在这个领域需要更多的研究.
科学领域:
- 神经科学和精神病学 在
- 临床药理学 临床药理学
- 发展心理学 发展心理学
背景情况:
- 自闭症谱系障碍 (ASD) 带来了各种各样的社会和行为挑战.
- 非典型的抗精神病药物经常用于ASD症状,如易怒和攻击性.
- 这些药物的比较疗效和安全性尚不清楚.
研究的目的:
- 进行一个网络元分析,对非典型抗精神病药物对ASD刺激的比较益处进行比较分析.
- 评估这些药物对各种ASD症状和副作用的益处和危害,与安慰剂或其他抗精神病药物相比.
- 评估ASD儿童和成人的短期,中期和长期结果.
主要方法:
- 系统地搜索多个数据库和试验注册表.
- 包括随机对照试验 (RCT),将非典型抗精神病药与安慰剂或其他非典型抗精神病药在ASD中进行比较.
- 网络对易怒和随机效应模型的分析,对其他结果进行GRADE确定性评估.
主要成果:
- 与安慰剂相比,Risperidone和aripiprazole在患有自闭症儿童的易怒性方面显示出潜在的短期益处 (低确定性证据).
- 卢拉西对易怒性几乎没有影响 (中度确定性证据).
- 其他结果的证据,如侵略性,体重增加和额外的皮拉米德副作用,由于偏见和不准确性的风险,非常不确定;一些低确定性证据表明对强迫症行为和不适当的言论有好处.
结论:
- 里斯佩里和阿里皮普拉可能有助于降低短期ASD儿童的易怒性.
- 其他益处和危害的证据有限,确定性低至非常低.
- 需要进一步进行高质量的RCT,特别是对成年人进行RCT,并提供透明的报告和一致的结果指标.
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