利用SARS-CoV-2的脆弱性与粘膜免疫功能和营养的合作伙伴关系:一个叙事审查
Richard J Head1, Jonathan D Buckley2, Jennifer H Martin3
1UniSA Clinical and Health Sciences, University of South Australia, Adelaide, South Australia.
Nutrition research reviews
|May 21, 2025
概括
维生素A和维生素D,,益生菌和胆乳等营养素可以增强上呼吸道粘膜免疫力. 这种营养支持可以增强对像SARS-CoV-2这样的病毒的保护,并改善疫苗反应.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 病毒学 病毒学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 通过上呼吸道粘膜屏障感染,使得早期干预具有挑战性.
- 增强粘膜防御可能会降低对SARS-CoV-2和流感的易感性,这是历史上重要的导致大流行的病毒.
研究的目的:
- 审查食物和营养物质如何促进粘膜的免疫准备对抗病毒感染.
- 探索营养策略,以最大限度地提高IgA对全身疫苗的反应,并提高鼻内疫苗的疗效.
- 确定支持粘膜免疫和疫苗反应的特定营养素.
主要方法:
- 文献综述总结了关于营养素和粘膜免疫力的研究.
- 确定对上呼吸道有潜在免疫调节作用的关键营养素和食品衍生成分.
主要成果:
- 维生素A和D,,益生菌,牛乳粉和耐药粉显示出促进粘膜免疫力的潜力.
- 这些营养素可能会增强粘膜体对现有系统性疫苗的免疫反应.
- 特别是维生素A可能会改善粘膜体对鼻腔内接种疫苗的反应.
结论:
- 针对粘膜免疫的营养干预提供了一种有希望的策略,可以增强对像SARS-CoV-2这样的呼吸道病毒的防御能力.
- 对营养和粘膜淋巴体免疫的进一步研究对于疫情准备至关重要.
- 通过饮食优化粘膜免疫力可以提高疫苗的有效性.
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