毒素菌感染的流行病学变化:法国里昂孕妇7年纵向研究,2017-2023年
Alvaro Roy1, Laurent Gaucher2, Damien Dupont3
1Department of Virology, Institute for Infectious Agents, Hospices Civils de Lyon, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France - National Centre for Epidemiology, Instituto de Salud Carlos III, Avenida de Monforte de Lemos 5, 28029 Madrid, Spain.
概括
在2017-2023年期间,孕妇中毒素菌感染血清流行率下降,但孕妇感染发病率保持稳定. 这凸显了对先天性毒素菌的持续监测和预防策略的需要.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 毒素菌感染流行病学在地理和时间上有所不同.
- 监测感染对于预防先天性毒素质症至关重要.
- 法国产前计划数据为感染趋势提供了洞察力.
研究的目的:
- 评估2017-2023年期间孕妇中毒素菌感染血清发病率和发病率的变化.
- 评估先天性毒素菌发病率的趋势.
- 确定与孕妇血清阳性相关的因素.
主要方法:
- 在法国里昂 (2017-2023) 进行了71,922例怀孕的长度回顾性研究.
- 对毒素状况,血清流行率和发病率的分析.
- 多变量后勤回归用于识别与血清阳性相关的因素 (年龄,原产地,人口密度,平价).
主要成果:
- 毒素菌病血清流行率从2017年的26.4%降至2023年的22.1% (p=0.003).
- 孕产妇感染发病率保持稳定,为1.3/1000例风险妊娠.
- 血清流行率随着年龄的增长而增加,在农村地区较低,但在多夫妇妇女中较高.
结论:
- 毒素菌病的血清流行率正在下降,但血清转化仍然稳定.
- 建议增加对血清阴性女性的测试.
- 在高收入国家,需要对先天性毒素菌进行持续监测和改进预防策略.
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