在体外受精中早期怀孕损失率与非体外受精怀孕相比
Peter M Doubilet1, Carol B Benson1, Elizabeth S Ginsburg2
1Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
概括
试管婴儿 (IVF) 不会独立增加早期怀孕损失的风险. 在考虑其他因素时,接受试管婴儿的女性与自然怀孕的女性有相同的流产概率.
科学领域:
- 生殖医学 生殖医学
- 产科 产科 产科 产科 产科
- 周围生理学 周围生理学
背景情况:
- 早期怀孕丧失 (EPL) 是辅助生殖技术的一个重要问题.
- 了解体外受精对EPL的独立影响对于患者咨询和临床实践至关重要.
研究的目的:
- 为了比较体外受精 (IVF) 和非IVF怀孕之间的EPL率.
- 为了确定试管婴儿是否对第一季度怀孕结果有独立的影响,控制母亲的年龄和阴道出血.
主要方法:
- 追溯分析了16458个单子子宫内怀孕,30年来已知第一季度结果.
- 根据受孕方式 (IVF与非IVF),孕妇年龄,阴道出血和超声检查结果评估EPL率.
- 后勤回归分析,以评估试管婴儿对EPL的独立影响,以混因素进行调整.
主要成果:
- 总体EPL率为20.3%. 这是一个很好的例子.
- 试管婴儿怀孕,晚期母亲年龄 (≥35岁) 和阴道出血与更高的EPL率 (P < .001) 有关.
- 后勤回归显示,受孕方式 (IVF与非IVF) 对EPL没有独立的影响 (P = .33仅对黄囊,P = .30对胚胎).
结论:
- 试管婴儿 (IVF) 不会独立地影响怀孕第一季度的结果.
- 在试管婴儿怀孕中流产的可能性与控制母亲年龄和阴道出血时的非试管婴儿怀孕相似.
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