深海冷微生物的致病性和抗生素耐药性的风险
Tianxueyu Zhang1,2, Yingchun Han3, Yongyi Peng3,4
1School of Oceanography, Shanghai Jiao Tong University, Shanghai, Shanghai, China.
mSystems
|May 21, 2025
概括
深海冷含有许多抗生素耐药性基因 (ARG) 和毒性因子 (VF),但对公共健康造成的风险很小. 这些发现对于深海资源开发期间的环境安全至关重要.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 环境科学 环境科学
背景情况:
- 深海的冷流是丰富的微生物,利用碳化合物和无机化合物.
- 这些独特的生态系统可能含有致病或抗生素耐药的微生物,在资源开发过程中构成潜在风险.
- 了解微生物病毒组和抗体组在"一个健康"的背景下至关重要,特别是在深海中人类活动的增加.
研究的目的:
- 综合分析全球深海冷微生物群落中毒性因子 (VF),抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE) 的多样性和分布.
- 评估这些极端环境中微生物带来的潜在公共卫生风险.
- 提供洞察力,了解病原性和抗生素耐药性的进化和生态影响.
主要方法:
- 分析了来自16个全球冷点的165个元基因组和33个元转录组.
- 在元基因组组装基因组 (MAG) 中识别和表征毒性因子 (VF) 和抗生素耐药性基因 (ARG).
- 对VF和ARG配置文件与其他环境环境进行比较分析.
主要成果:
- 总共有2,353个VF被确定,主要与诸如粘附之类的间接致病学有关.
- 检测到近10万个ARG,高风险ARG构成很小一部分 (11.22%) 和存在于低丰度.
- 与其他环境相比,冷中的微生物显示出明显的VF和ARG配置文件,有横向基因转移的证据.
结论:
- 深海冷沉积物由于高风险的ARG和VF的丰度较低,对公共健康造成的风险最小.
- 这些生态系统作为各种ARG和VF的储存库,对微生物进化和基因转移有影响.
- 这些发现对于深海资源开发和研究活动中的环境安全评估至关重要.
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