一个反对纯度的案例:优先考虑翻译性多物质使用研究
Cassandra Gipson1, Amanda Fallin-Bennett2, Jibran Khokhar3
1Department of Pharmacology and Nutritional Sciences, College of Medicine.
Current opinion in psychiatry
|May 21, 2025
概括
临床前成研究应纳入多物质使用 (PSU) 模式,而不仅仅是单一的药物. 包括有实践经验的人在内对于开发有效治疗成危害的方法至关重要.
科学领域:
- 神经科学是一个神经科学.
- 药物成科学 药物成科学
- 翻译研究是翻译研究.
背景情况:
- 临床前成研究经常模拟单一物质使用,这并不反映现实世界多重物质使用 (PSU).
- 公共服务使用非常普遍,涉及在不断发展的非法药物供应中复杂的相互作用.
- 目前的模型缺乏吸毒者的专业知识,阻碍了科学进步.
研究的目的:
- 倡导将临床相关的PSU模式纳入临床前成模型.
- 强调包括有实践经验的人作为翻译研究的合作者的关键作用.
- 为了解决孤立研究成性药物的局限性.
主要方法:
- 审查和批评当前的临床前成研究方法.
- 论证一个范式的转移远离"纯度"在实验设计.
- 重点是整合现实世界的多种物质使用场景.
主要成果:
- 临床前模型经常无法反映人类物质使用障碍的复杂性.
- 排除具有实体经验的个人限制了研究结果的范围和适用性.
- 在了解PSU的神经行为基础方面存在很大的差距.
结论:
- 对成药物的临床前研究必须超越单一物质范式,包括PSU.
- 与有实践经验的人进行有意义的合作对于开发有效的成治疗方法至关重要.
- 需要在整个翻译频谱进行进一步的研究,以解决PSU.
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