相关实验视频
Updated: May 22, 2025
13:28
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
27.4K
在吸入性皮质类固醇的喘儿童中,喘控制水平,肺功能和支气管扩展剂反应之间的关系
Javier Mallol1, Viviana Aguirre-Camposano1, Alejandro Gallardo1
1Department of Pediatric Respiratory Medicine, Hospital El Pino, University of Santiago de Chile, Santiago.
概括
全球喘倡议标准 (GINAc) 在儿童中发现的非控制性喘病例比喘控制测试 (ACT) 更多. 肺功能测试可能有助于识别有潜在问题的控制性喘.
科学领域:
- 儿科肺病学 儿科肺病学
- 喘管理 喘管理
- 临床评估工具 临床评估工具
背景情况:
- 对儿童的喘控制评估对于有效管理至关重要.
- 吸入性皮质类固醇是儿科喘治疗的基石.
- 在主观和客观的喘控制措施之间存在差异.
研究的目的:
- 为了比较全球喘倡议标准 (GINAc) 和喘控制测试 (ACT) 在评估儿科喘控制.
- 评估肺功能 (LF) 测试的实用性,包括螺旋计和支气管扩展剂响应 (BDR),用于识别不受控制的喘.
- 探索LF测试与全面喘评估的问卷一起发挥的作用.
主要方法:
- 一项涉及149名接受吸入性皮质类固醇的儿童的研究.
- 使用GINAc和ACT问卷进行喘控制的评估.
- 螺旋测量和支气管扩展剂反应 (BDR) 测试的性能.
主要成果:
- 与ACT (25.9%) 相比,GINAc发现的患有非控制性喘的儿童显著多 (65.8%).
- 异常的肺功能在GINAc定义的不受控制的喘中更为普遍.
- 支气管扩展剂反应在GINAc定义的失控喘和ACT定义的失控喘中也更频繁.
结论:
- 在检测儿童失控喘时,GINAc似乎比ACT更敏感.
- 螺旋计和BDR可以补充喘控制问卷,特别是用于识别有亚临床异常的受控病例.
- 整合LF测试可以完善喘控制的评估,并指导治疗调整.
相关概念视频
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
183
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
183
01:26COPD: Management Using Bronchodilators and Corticosteroids
166
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
166
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:17Drugs Used in Lower Respiratory Disorders: Overview
329
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
329
01:20Asthma: Pathogenesis and Management
298
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
298
01:19Antiasthma Drugs: Leukotriene Modifiers
208
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
208