来自Pinus massoniana的节点中的肝保护性二烯
Jia-Qi Chen1, Ling-Zhi Zhang1, Jie Ma1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Journal of Asian natural products research
|May 21, 2025
概括
研究人员从中国传统医药Pinus massoniana中分离出了新的二烯. 一些化合物对肝细胞中氧化应激产生显著的肝保护作用.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统的中国医学,Pini Lignum Nodi (Pinus massoniana),是生物活性化合物的来源.
- 迪特尔是一种具有多种生物活动的自然产品类.
- 氧化应激对肝损伤起着至关重要的作用.
研究的目的:
- 从Pini Lignum Nodi.中分离和表征新的双烯.
- 评估隔离化合物对氧化损伤的肝脏保护活性.
主要方法:
- 使用色谱技术分离化合物.
- 通过光谱方法 (NMR,MS) 和ECD计算来阐明结构.
- 使用HepG2细胞和H2O2诱导的氧化损伤模型对肝保护活性进行体外评估.
主要成果:
- 鉴定出了三种新型的二,松鼠D-F (1-3),以及十二种已知的二.
- 化合物4-15表现出中度的肝保护活性.
- 化合物5-15显示显著增强的肝保护疗效相比积极控制,bicyclol.
结论:
- 松树 (Pinus massoniana) 含有新型二烯,具有潜在的治疗应用.
- 孤立的二烯,特别是5-15化合物,表现出有前途的肝脏保护性质.
- 对这些化合物的进一步研究可能会导致肝脏疾病的新疗法.
更多相关视频
08:20Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
Published on: December 2, 2022
1.8K
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.1K
相关概念视频
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
02:26Defenses Against Pathogens and Herbivores
22.7K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
22.7K