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使用第一季度的双胞胎预产前的预测:cffDNA分数,plgf和map

Ran Svirsky^1,2,3, Adi Sharabi-Nov^4,5, Ron Maymon^3,6

¹Medical Genetic Unit, Department of Obstetrics and Gynecology, Samson Assuta Ashdod University Hospital, Ashdod, Israel.

Prenatal diagnosis

|May 21, 2025

概括

在双胞胎怀孕中,低的第一季度无细胞胎儿DNA分数 (cffDNAF) 有效地选早期孕前. 将cffDNAF与胎盘生长因子 (PlGF) 和平均动脉压 (MAP) 结合起来,进一步提高了查准确度.

科学领域:

孕产妇和胎儿医学孕产妇和胎儿医学
遗传学是一个遗传学.
产科产科产科产科产科

背景情况:

双胞胎怀孕中产前带来了重大风险,需要有效的早期查方法.
第一个三个月的查对于高风险怀孕的及时干预至关重要.

研究的目的:

评估无细胞胎儿DNA分数 (cffDNAF) 作为第一季度查标志物对预先怀孕症的疗效,需要在双胞胎怀孕37周之前分娩.
评估cffDNAF与胎盘生长因子 (PlGF),平均动脉压 (MAP) 和子宫动脉脉动指数 (UtA-PI) 的联合性能.

主要方法:

在第一季度对双胞胎怀孕的女性进行前性评估.
分析cffDNAF,PlGF,MAP和UtA-PI作为潜在的孕前查标志物.
单独和组合使用接收器操作特征曲线 (AUROC) 下面面积的标记器性能比较.

主要成果:

与未受影响怀孕 (14%,p < 0.001) 相比,在患有妊娠前的妇女中观察到较低的cffDNAF (9.0%).
cffDNAF的AUROC值为0.73,plGF的AUROC值为0.71,MAP的AUROC值为0.61,其中PgF的AUROC值为0.73,PgF的AUROC值为0.73,PgF的AUROC值为0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.73,PgF的AUROC值是0.61.
结合cffDNAF,PlGF和MAP,获得了0.89的AUROC,敏感度为81%,特异性为90%.

结论:

第一季度cffDNAF是一个有价值的查标记,用于在双胞胎怀孕中早期发病的孕前.
cffDNAF与plgf和map的结合显著提高了查性能.
在这个队列中,UtA-PI并没有提高诊断准确度.

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