相关实验视频

Updated: May 23, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

对评论的回应"在Omics中实验设计和功率计算使用Cosinor模型检测循环节律"的评论

RuoFei Yin¹, George C Tseng¹

¹Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Statistics in medicine

|May 21, 2025

概括

对生物节奏的统计功率计算在均抽样时是准确的,但在不均抽样时被高估. 这项研究纠正了对不均采样设计的功率错误计算,更新了CircaPower R包.

科学领域:

时间生物学时间生物学
统计建模统计建模
生物信息学是一种生物信息学.

背景情况:

在生物节律研究的功率计算中,非中心参数 (ncp) 之前被错误计算.
这种错误主要影响统计功率估计,特别是在不均的抽样设计下.

更多相关视频

A Computational Method to Quantify Fly Circadian Activity

A Computational Method to Quantify Fly Circadian Activity

Published on: October 28, 2017

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

相关概念视频

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...