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与代谢功能障碍相关的脂肪性肝病在艾滋病毒感染者中

Arijeet K Gattu^1,2,3, Lindsay T Fourman^1,3

¹Metabolism Unit and Division of Endocrinology, Massachusetts General Hospital.

Current opinion in HIV and AIDS

|May 21, 2025

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 在艾滋病毒感染者 (PWH) 中更具侵略性. 由于艾滋病毒特异性因素加剧了MASLD-HIV进展,因此需要量身定制的方法.

科学领域:

肝病学肝病学是一种肝病学.
传染性疾病传染性疾病
代谢障碍代谢障碍代谢障碍

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 在艾滋病毒感染者 (PWH) 中非常普遍.
在PWH中,MASLD是导致发病率和死亡率的重要因素.
最近在MASLD命名和治疗方面取得的进展突显出需要针对HIV的具体考虑.

研究的目的:

审查有关PWH中MASLD的科学现状.
在艾滋病毒的背景下强调MASLD病理生理学的独特方面.
讨论最近的MASLD发展对PWH的影响.

主要方法:

关于PWH中MASLD的当前文献的综述.
对影响MASLD进展的HIV特异性因素的分析.
在艾滋病毒的背景下对新兴的MASLD疗法的评估.

主要成果:

在PWH (MASLD-HIV) 中的MASLD表现出比HIV阴性个体更具侵略性的临床过程.
特定于艾滋病毒的因素 (身体组成,免疫激活,肠道透性,ART) 会使MASLD-HIV恶化.
虽然MASLD存在有前途的疗法,但它们在PWH中的评估缺乏,尽管一些药物显示出潜力.

结论:

在PWH中,MASLD显著导致肝脏和心血管疾病.
病理生理差异需要针对PWH量身定制的MASLD管理策略.
一般MASLD护理的进步需要适应PWH的独特需求.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒艾滋病病毒脂质缩症艾滋病病毒脂质缩症马什 (MASH) 是一个非常重要的产品.肝脏肥胖症肝脏肥胖症与代谢功能障碍相关的脂肪性肝病.

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