平衡多药和并发症管理:心血管健康
Alex E Rock1,2, Matthew L Russell3, Virginia A Triant2,4
1Department of Pharmacy.
Current opinion in HIV and AIDS
|May 21, 2025
概括
现在,对于40至75岁的艾滋病毒感染者进行心血管疾病 (CVD) 的初级预防,建议使用静止剂治疗. 在开始治疗时,必须仔细考虑多药性.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
背景情况:
- 艾滋病毒感染者 (PWH) 面临慢性疾病的风险增加,需要与抗逆转录病毒疗法 (ART) 一起进行治疗.
- 心血管疾病 (CVD) 是PWH的一个重大问题,需要有效的预防策略.
- 多药学在管理PWH的慢性疾病方面提出了独特的挑战.
研究的目的:
- 审查他类药物治疗在预防PWH中心血管疾病中的作用.
- 讨论平衡慢性疾病管理与抗逆转录病毒疗法 (ART) 和多药.
- 为提供关于在PWH中进行初级心血管疾病预防时启动他类药物治疗的指导.
主要方法:
- 审查最近的临床试验数据,包括REPRIEVE试验.
- 对卫生和人类服务部 (HHS) 当前指南的分析.
- 在PWH中考虑药物相互作用和多药学.
主要成果:
- REPRIEVE试验显示,他类药物治疗可显著降低低至中等风险的PWH中心血管疾病事件.
- 现在,HHS建议在40至75岁的PWH患者中进行他类药物治疗,以预防心血管疾病.
- 开始使用他类药物应该与已建立的心血管疾病预防指南保持一致,同时考虑多药.
结论:
- 对于40至75岁的PWH患者进行初级心血管疾病预防,建议使用静止剂治疗.
- 对于所有老化的PWH,必须仔细考虑多药.
- 对慢性病的有效管理对于降低发病率和死亡率以及促进PWH健康老龄化至关重要.
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