关于艾滋病毒的神经并发症的最新情况
1Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Current opinion in HIV and AIDS
|May 21, 2025
概括
由于抗逆转录病毒治疗 (ART) 的寿命延长,艾滋病毒感染者 (PWH) 的神经并发症正在增加. 本综述详细介绍了与艾滋病毒有关的脑部问题,强调神经认知障碍和需要更好的管理策略.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 由于抗逆转录病毒治疗 (ART) 导致艾滋病毒 (PWH) 感染者的寿命增加,与神经系统并发症的增加有关.
- 了解这些神经系统的后续是提高患者护理和结果的关键.
研究的目的:
- 为提供PWH.神经复杂症的最新审查.
- 涵盖神经认知障碍,神经病变,神经机遇性感染和其他相关疾病.
主要方法:
- 关于最近关于艾滋病毒相关神经复杂症的发现的文献综述.
- 综合有关病理生理学,衰老影响,患病率,诊断工具和生物标志物的信息.
主要成果:
- 艾滋病毒蛋白 (gp120,Nef) 和神经炎症有助于神经元损伤.
- 老龄化加剧了神经问题,艾滋病毒相关的神经认知障碍 (HAND) 和阿尔茨海默病相关痴呆症 (AD/ADRD) 的高患病率.
- 神经认知查工具 (IHDS,MoCA) 和生物标志物/神经成像帮助早期检测和监测HAND.
结论:
- 需要全面的医疗保健策略来管理PWH的神经并发症.
- 有针对性的干预,改进的诊断和量身定制的治疗是必不可少的.
- 减轻艾滋病毒对大脑健康的影响对于改善PWH生活质量至关重要.
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