由二硫化物桥介导的循环德克斯特林植入的热/氧化解双响应聚合物,用于调节药物输送
Zhijia Yan1, Xin Xu1, Jinku Xu1
1School of Chemistry & Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Journal of biomaterials science. Polymer edition
|May 21, 2025
概括
一种新的双响应聚合物PNIPAM-SS-β-CD被开发用于向癌症治疗. 它表现出增强的黄素加载和受控释放,由谷氨引发的快速释放,展示了其治疗潜力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 瘤细胞表现出高水平的降解谷氨,能够分裂二硫化物键.
- 开发先进的药物输送系统对于有效的癌症治疗至关重要.
研究的目的:
- 为了合成和表征一种新的热/氧化还原双反应聚合物,PNIPAM-SS-β-CD,用于向癌症治疗.
- 评估聚合物的生物相容性,药物载荷能力和受控释放特征.
主要方法:
- 通过N-异烯胺 (N-isopropylacrylamide) (NIPAM) 和单甲基化β-环极素 (MA-SS-β-CD) 的共聚合合成PNIPAM-SS-β-CD.
- 聚合物性质的表征,包括分子量,β-CD含量和相位过渡温度.
- 对细胞毒性,血液溶解,药物负载 (黄素) 和体外释放动力学的评估.
主要成果:
- 合成的PNIPAM-SS-β-CD聚合物具有53.75kDa的分子量和45.5%的β-CD含量.
- 该聚合物表现出优异的生物相容性,细胞活力>95%,没有溶血活性.
- 与PNIPAM相比,PNIPAM-SS-β-CD在24小时内增加了黄素负载和持续释放的5.5倍.
- 在减少谷氨 (GSH) 的反应中观察到快速的药物释放,这表明了氧化还原反应.
结论:
- PNIPAM-SS-β-CD是一种生物相容,双响应的聚合物,具有增强药物递送的潜力.
- 聚合物的热/氧化解敏感性允许控制释放诸如黄素之类的治疗剂.
- 这种材料具有针对性癌症治疗的前景,因为它能够响应瘤微环境.
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