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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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对动脉样硬化的免疫疗法.

Claudia Monaco1, Coleen A McNamara2, Bram Slütter3

  • 1Kennedy Institute of Rheumatology, Old Road Campus, Roosevelt Drive, OX3 7FY University of Oxford, Oxford, UK.

Physiological reviews
|May 21, 2025
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概括
此摘要是机器生成的。

动脉样硬化是导致死亡的主要原因,是一种涉及免疫细胞的炎症性疾病. 新兴的免疫疗法通过向这些免疫反应来治疗心血管疾病有前途.

关键词:
动脉样硬化是一种动脉样硬化.心血管疾病是什么心血管疾病免疫学 免疫学 免疫学免疫治疗是一种免疫疗法.炎症 炎症是一种炎症.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 心血管医学 心血管医学
  • 动脉样硬化的发病因子

背景情况:

  • 心血管疾病,主要是动脉样硬化,是全球主要的健康负担.
  • 动脉样硬化现在被理解为一种由脂质驱动的炎症性疾病,涉及动脉内的复杂免疫细胞相互作用.
  • 目前的治疗重点是脂质和高血压,尽管该疾病的炎症性已被证实.

研究的目的:

  • 审查对免疫细胞子集在动脉样硬化中的作用的最新见解.
  • 讨论当前和未来的免疫治疗策略来治疗动脉样硬化心血管疾病.
  • 突显心血管疾病免疫治疗中患者分层的必要性.

主要方法:

  • 审查关于动脉样硬化和免疫学的当前科学文献.
  • 对针对心血管疾病的免疫疗法的临床试验数据的分析.
  • 综合免疫系统参与动脉疾病的新兴概念.

主要成果:

  • 临床试验表明,免疫疗法通常耐受良好,可以减少炎症和心血管终点.
  • 免疫系统包括先天性和适应性组成部分,在动脉样硬化斑块的发展和进展中发挥着关键作用.
  • 从脂质驱动到炎症病原体的理解转变需要新的治疗方法.

结论:

  • 动脉样硬化基本上是一种由免疫系统失调驱动的炎症状况.
  • 免疫疗法是治疗动脉样硬化心血管疾病的一个有希望的前沿.
  • 需要进一步的研究来确定最佳的免疫治疗标和患者选择标准.