室腔辅助器件在儿科限制性和多变性心肌病中使用:一个ACTION注册表分析
Deepa Mokshagundam1, Muhammad F Shezad2, Jennifer Conway3
1From the St Louis Children's Hospital, St Louis, Missouri.
概括
室腔辅助器件 (VAD) 为儿科限制性心肌病 (RCM) 患者提供了一个可行的选择,但对多变性心肌病 (HCM) 的结果不太有利. 这项研究分析了在这些罕见的儿科心脏病中使用VAD的情况.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 机械循环支持 机械循环支持
- 心肌病研究研究 心肌病研究
背景情况:
- 室腔辅助器件 (VAD) 很少用于儿科限制性心脏病 (RCM) 和多变性心肌病 (HCM).
- 了解这些特定儿科群体的VAD结果对于治疗策略至关重要.
研究的目的:
- 描述了接受VAD支持的RCM和HCM儿科患者的结果.
- 在这个罕见的队列中评估VAD的安全性和有效性.
主要方法:
- 对34名患有RCM或HCM的儿科患者接受VAD的回顾性分析.
- 数据收集自先进心脏疗法改善结果网络 (ACTION) 注册表 (2012年3月至2024年12月).
- 包括左侧VAD (LVAD),双心室VAD (BiVAD) 和全人工心脏 (TAH) 设备.
主要成果:
- 25名患者患有RCM,9名患有HCM;中位数年龄2.5岁,体重11.8公斤.
- 植入时的高疾病严重程度:38.2% 在INTERMACS概况1上,41.2% 在ECMO上.
- 移植率为73.5%;11.8%在设备上死亡,11.8%在设备上活着.
结论:
- 选择儿科RCM患者的VAD支持是一个合理的策略.
- 儿科HCM患者在VAD上的结果不那么有利,死亡与HCM诊断,BiVAD支持和不良事件有关.
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