在前列腺癌患者中对热闪管理的审查
Kevin Lawrence Lin1, Barak Talmor1, Megan Crumbaker1
1The Kinghorn Cancer Centre, St Vincent's Hospital Sydney, Darlinghurst, NSW 2010, Australia.
The Journal of clinical endocrinology and metabolism
|May 21, 2025
概括
热 (血管运动症状) 的有效管理对于正在接受前列腺癌雄激素剥夺疗法 (ADT) 的男性至关重要. 荷尔蒙疗法和某些非荷尔蒙药物提供缓解,新药正在调查中.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 血管运动症状 (VMS),包括热,是前列腺癌患者的雄激素剥夺疗法 (ADT) 的常见副作用.
- 有效管理VMS对于改善生活质量和生存率在这个人群中至关重要.
- 了解热病理生理学的进步为新的治疗策略铺平了道路.
研究的目的:
- 对前列腺癌男性的VMS管理策略的当前景观进行审查.
- 综合各种治疗方案的有效性和局限性的证据.
- 在ADT的背景下突出显示VMS的新兴疗法.
主要方法:
- 使用PubMed和Embase数据库进行了文献搜索.
- 审查的重点是研究针对前列腺癌患者进行ADT的VMS管理.
- 来自临床试验和审查的证据被综合起来,概述了治疗选择.
主要成果:
- 激素疗法,特别是透皮雌醇,对VMS非常有效,具有作为ADT替代品的潜力.
- 非激素选择如 gabapentin,oxybutynin 和抗抑郁药显示有效性,但可能有副作用.
- 针对下丘脑路径 (例如,fezolinetant) 和非药物方法 (CBT,针) 的新型药物显示出希望,但需要进一步验证.
结论:
- 临床医生必须准备好为ADT副作用提供基于证据的VMS管理.
- 既定疗法 (氧丁宁,抗抑郁药) 和激素治疗 (透皮雌激素) 是关键的选择.
- 新兴的治疗方法,包括神经素抗剂,为未来的治疗提供了可能性,尽管应该考虑潜在的副作用,如雌激素的妇产不良.
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