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Updated: Jun 1, 2026

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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在体内,CRISPR激活屏幕识别了乙-CoA结合蛋白作为骨转移的驱动因素

Hongqi Teng1, Qinglei Hang1, Caishang Zheng2

  • 1Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Science translational medicine
|May 21, 2025
PubMed
概括

乙辅酶A (CoA) 结合蛋白 (ACBP) 通过重编程癌细胞脂质代谢来驱动骨转移. 向脂肪酸氧化 (FAO) 或诱导铁亡可以治疗骨转移.

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...