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Updated: May 23, 2025

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SARS-CoV-2 诱导中性粒细胞的脱粒化和分化为与严重的COVID-19相关的髓状细胞衍生的抑制细胞

Leon L Hsieh1,2, Elizabeth A Thompson2, Nirvani P Jairam1

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Science translational medicine
|May 21, 2025
PubMed
概括

严重的COVID-19涉及具有增加LOX-1表达的中性粒细胞,作为髓质衍生抑制细胞. SARS-CoV-2 直接激活中性粒细胞,促进免疫抑制,并建议PD-L1 抑制作为治疗方法.

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