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微纳米塑料 (<4微米):在静脉输注过程中,这是一个重要的但被忽视的担忧

Penghui Li¹, Haoming Xu², Qingcun Li³

¹School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China.

Journal of hazardous materials

|May 21, 2025

概括

静脉输液产品 (IVIPs) 在治疗期间将微纳米塑料 (MNP) 释放到血液中. 这些塑料颗粒对健康构成重大风险,需要对IVIP安全性进行评估.

科学领域:

环境科学环境科学
材料科学材料科学材料科学
公共卫生公共卫生

背景情况:

微纳米塑料 (MNPs) 在人类血液和动脉瘤中被检测到,与心血管问题有关.
人体循环中MNP的来源,特别是直接引入的途径,尚不清楚.
静脉输液产品 (IVIP) 是直接MNP进入血液的潜在来源.

研究的目的:

为了研究在模拟静脉注射治疗期间从常用的IVIP释放MNP.
通过IVIP引入的MNP类型和度的确定和量化.
评估与IVIPs的MNP相关的健康风险.

主要方法:

进行了模拟的静脉注射治疗.
修改后的拉曼光谱法用于识别MNP类型.
使用扫描电子显微镜与能量分散式X射线光谱学 (SEM-EDS) 来描述MNP形态和大小.

主要成果:

在六个不同的IVIP中检测到聚烯和聚乙烯化物MNP.
观察到的MNP范围为10nm至3.6μm.
在模拟治疗期间,MNP的数量度达到 (5.82 ± 0.86) × 10^4项/L.

结论:

使用常见IVIP的静脉治疗将MNP直接引入人体血液中.
这些MNP,特别是纳米塑料,对健康构成严重风险.
在IVIP安全性评估中,必须考虑MNP的存在和影响.

关键词:

人类血液的人类血液.人类健康人类健康人类健康静脉注射输液产品静脉注射输液产品微塑料是一种微塑料.纳米塑料是一种纳米塑料.

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