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Updated: May 23, 2025

Author Spotlight: Establishing CENP-E Knockout HeLa Cells – A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors
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Author Spotlight: Establishing CENP-E Knockout HeLa Cells – A Novel Approach to Study Kinesin-7 CENP-E Biology and its Inhibitors

Published on: June 23, 2023

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在癌症中,CSDE1通过通过CSDE1-eIF3a调控复合体调节RPA2来增强基因毒性药物耐药性

Jia-Jia Cui1, Cheng-Xian Guo2, Jun Li3

  • 1Department of Geratic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan 410008, PR China; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan 410008, PR China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, Hunan 410000, PR China; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China; Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research, Shenzhen 518000, PR China.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
|May 21, 2025
PubMed
概括

含有E1 (CSDE1) 的冷震域通过调节DNA修复通路并抑制免疫信号来增强癌细胞对基因毒药物的抵抗力. 作为一个三元复杂的枢纽,CSDE1的作用为改善癌症治疗灵敏度提供了新的策略.

关键词:
CSDE1 关于我们的生活修复DNA的修复DNA的修复基因毒性药物 基因毒性药物在RPA2中使用RPA2.cGAS-STING 的使用情况.

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