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产前暴露于和与婴儿听觉功能的关联

Sandra Fortin¹, Benoît Jutras², Maryse F Bouchard³

¹École d'orthophonie et d'audiologie, Université de Montréal, Montréal, Québec, Canada.

International journal of pediatric otorhinolaryngology

|May 21, 2025

概括

婴儿早期的暴露与听觉功能的降低有关,特别是外皮毛细胞的反应. 暴露于与婴儿听力没有明确的关联. 建议进行进一步的研究.

科学领域:

环境健康环境健康
神经发育毒理学神经发育毒理学
听力学听力学是指听力学.

背景情况:

早期的大脑发育容易受到环境毒素的影响.
(Pb) 和 (Hg) 是常见的发育毒素.
了解它们对婴儿听觉功能的影响至关重要.

研究的目的:

调查产前 (Pb) 和 (Hg) 暴露与婴儿的听觉功能之间的关联.
使用耳声发射 (OAEs) 和最小听觉响应水平 (MRL) 评估听觉功能.
为了确定早期接触这些金属是否会影响婴儿的听力.

主要方法:

在6个月大的婴儿中,使用TEOAEs,DPOAEs和MRL来评估听觉功能.
分析了母亲的血液样本 (1st/3rd trimester) 和带血液,以检测Pb和Hg的度.
环境化学物质和婴儿发育 (MIREC-ID) 母婴研究队列提供了研究人口.

主要成果:

较高的母体血 (Pb) 度与减少的OAE显著相关,表明内耳功能受损.
这种关联在短暂唤起的OAEs (TEOAEs),特别是可重复性方面更强烈,在左耳中更明显.
在 (Hg) 暴露和婴儿听觉功能 (OAE或MRL) 之间没有明确的关联.

结论:

产前暴露于低水平的 (Pb) 与婴儿的外皮毛细胞功能减少有关.
这表明,由于发育期的暴露,内耳功能可能会下降.
需要进行更大规模的研究来证实这些发现及其对婴儿听力健康的影响.

关键词:

审计功能审计功能婴儿婴儿婴儿婴儿婴儿婴儿领导领导领导领导领导在MIREC研究中,MIREC研究水星水星水星水星水星产前暴露在产前暴露.

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