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Updated: May 23, 2025

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction
00:05

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

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将激动剂逆转为抑制剂:mTOR降解剂的发展

Liquan Zhu1, Siyi Fu2, Longfei Ma2

  • 1Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, PR China; General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, PR China.

European journal of medicinal chemistry
|May 21, 2025
PubMed
概括

研究人员使用激动剂开发了新的mTOR向PROTAC,证明了有效的蛋白质降解. 这一新战略扩大了针对蛋白质降解的治疗应用.

关键词:
自自是一种自的过程.降解降解是一种降解.这就是 PROTACs.蛋白质组学是指蛋白质组学.在mTOROR中使用mTOR.

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